| Southampton FC vs. Liverpool FC | 11-24-2024
Sunday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Chelsea FC | 12-4-2024
Wednesday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Aston Villa FC vs. Southampton FC | 12-7-2024
Saturday
TBD | Villa Park in Birmingham, United Kingdom | View Tickets |
| Southampton FC vs. Tottenham Hotspur FC | 12-15-2024
Sunday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| EFL Cup: Southampton FC vs. Liverpool FC (Date: TBD) | 12-17-2024
Tuesday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Fulham FC vs. Southampton FC | 12-22-2024
Sunday
TBD | Craven Cottage in London, United Kingdom | View Tickets |
| Southampton FC vs. West Ham United FC | 12-26-2024
Thursday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Crystal Palace FC vs. Southampton FC | 12-29-2024
Sunday
TBD | Selhurst Park in London, United Kingdom | View Tickets |
| Southampton FC vs. Brentford FC | 1-4-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Manchester United FC vs. Southampton FC | 1-16-2025
Thursday
TBD | Old Trafford in Manchester, United Kingdom | View Tickets |
| Southampton FC vs. Newcastle United FC | 1-25-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. AFC Bournemouth | 2-15-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Brighton & Hove Albion FC | 2-22-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Chelsea FC vs. Southampton FC | 2-26-2025
Wednesday
TBD | Stamford Bridge in London, United Kingdom | View Tickets |
| Liverpool FC vs. Southampton FC | 3-8-2025
Saturday
TBD | Anfield in Liverpool, United Kingdom | View Tickets |
| Southampton FC vs. Wolverhampton Wanderers | 3-15-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Crystal Palace FC | 4-2-2025
Wednesday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Tottenham Hotspur FC vs. Southampton FC | 4-5-2025
Saturday
TBD | Tottenham Hotspur New Stadium in London, United Kingdom | View Tickets |
| Southampton FC vs. Aston Villa FC | 4-12-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| West Ham United FC vs. Southampton FC | 4-19-2025
Saturday
TBD | London Stadium At Queen Elizabeth Olympic Park in London, United Kingdom | View Tickets |
| Southampton FC vs. Fulham FC | 4-26-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Leicester City FC vs. Southampton FC | 5-3-2025
Saturday
TBD | King Power Stadium in Leicester, United Kingdom | View Tickets |
| Southampton FC vs. Manchester City FC | 5-10-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Everton FC vs. Southampton FC | 5-18-2025
Sunday
TBD | Goodison Park in Liverpool, United Kingdom | View Tickets |
| Southampton FC vs. Arsenal FC | 5-25-2025
Sunday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
