| Nicholls Colonels Football vs. Incarnate Word Cardinals | 8-23-2025
Saturday
TBD | John L. Guidry Stadium in Thibodaux, LA | View Tickets |
| Troy Trojans Football vs. Nicholls Colonels | 8-30-2025
Saturday
TBD | Veterans Memorial Stadium - AL in Troy, AL | View Tickets |
| Nicholls Colonels Football vs. West Georgia Wolves | 9-6-2025
Saturday
TBD | John L. Guidry Stadium in Thibodaux, LA | View Tickets |
| Texas State Bobcats Football vs. Nicholls Colonels | 9-20-2025
Saturday
TBD | UFCU Stadium in San Marcos, TX | View Tickets |
| Eastern Kentucky Colonels Football vs. Nicholls Colonels | 9-27-2025
Saturday
TBD | Roy Kidd Stadium in Richmond, KY | View Tickets |
| Lamar Cardinals Football vs. Nicholls Colonels | 10-4-2025
Saturday
TBD | Provost Umphrey Stadium in Beaumont, TX | View Tickets |
| Nicholls Colonels Football vs. McNeese State Cowboys | 10-25-2025
Saturday
TBD | John L. Guidry Stadium in Thibodaux, LA | View Tickets |
| Nicholls Colonels Football vs. Houston Christian Huskies | 11-1-2025
Saturday
TBD | John L. Guidry Stadium in Thibodaux, LA | View Tickets |
| University of Texas-Rio Grande Valley Football vs. Nicholls Colonels | 11-8-2025
Saturday
TBD | H-E-B Park in Edinburg, TX | View Tickets |
| Nicholls Colonels Football vs. Northwestern State Demons | 11-15-2025
Saturday
TBD | John L. Guidry Stadium in Thibodaux, LA | View Tickets |
| Southeastern Louisiana Lions Football vs. Nicholls Colonels | 11-20-2025
Thursday
TBD | Strawberry Stadium in Hammond, LA | View Tickets |
